Exorbitant sitting, commonly termed sedentary time, now resides as the default setting for the large majority of individuals, with those identified at high risk of chronic disease spending up to 80% of their waking time sedentary. Current physical activity guidelines now include specific recommendations to reduce and interrupt prolonged sitting. These guidelines have been informed by emerging research suggesting that sitting time is an independent risk factor for cardiometabolic morbidity and mortality. In recent years, epidemiological research has been complemented by acute experimental studies showing that breaking up bouts of prolonged sitting with standing or light-intensity activity elicits significant benefits on markers of metabolic health. However, there is considerable inter-individual variability in the effectiveness of such interventions…

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